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Tuesday, June 19, 2018 Wednesday, June 20, 2018 Thursday, June 21, 2018 Friday, June 22, 2018

Tuesday, June 19, 2018
  Activity
13:00 -15:15 Registration
15:15 -15:45 Welcome address and congress opening
15:45 -16:30 Opening Lecture: Drugs for purinergic targets.
Christa Müller, University of Bonn, Germany
16:30 - 18:10
Symposium 1 - Purinergic signaling in parasite-caused diseases
Chairs: Luis Carlos Crocco Afonso, Federal University of Ouro Preto, Brazil
Maria Pilar Aoki, National University of Cordoba, Argentina
1. Role of purinergic signaling during human and experimental Chagas disease
Maria Pilar Aoki, National University of Cordoba, Argentina
2. Endothelial P2Y receptors and NTPDases 2 and 3 contribute to leukocyte adhesion during schistosomiasis
Claudia Lucia Martins Silva, Federal University of Rio de Janeiro, Brazil
3. Purinergic signaling and the PfSR25 parasite GPCR-like for sensing changes in Plasmodium environment
Celia R.Garcia, University of São Paulo, Brazil
4. P2X7 drives Th1 vs Tfh cell differentiation in experimental malaria
Maria Regina D’Império Lima, University of São Paulo, Brazil
5. Oral Communication: Recruitment of Adenosine A2b receptor is important for dendritic cell inhibition by metacyclic promastigotes of Leishmania amazonensis
Amanda Braga de Figueiredo, Federal University of Ouro Preto, Brazil
Symposium 2 - Pharmacology of Purinoreceptors
Chairs: Ivar von Kugelgen, University of Bonn, Germany
Rafael Franco, University of Barcelona, Spain
1. Functional selectivity and biased agonism in individual receptors and in receptor heteromers
Rafael Franco, University of Barcelona, Spain
2. FRET-based biosensors reveal dynamic receptor activation of the A1 adenosine receptor
Carsten Hoffmann, University of Jena, Germany
3. Pharmacology of the platelet P2Y12 receptor
Ivar von Kügelgen, University of Bonn, Germany
4. Avermectins, Alcohol use disorder and P2X4 receptors
Daryl L. Davies, University of Southern California, USA
5. Oral Communication: P2X7 receptor is a major modulator of extracellular ATP concentration and related immune response in oncogenesis
Elena De Marchi, University of Ferrara, Italy
Symposium 3 - Adenosine control of synaptic activity & neuropsychiatric diseases
Chairs: Rodrigo Cunha, University of Coimbra, Portugal
Lisiane Porciuncula, Federal University of Rio Grande do Sul, Brazil
1. Sex differences in the effects of caffeine in the Attention Deficit and Hyperactivity Disorder
Lisiane Porciuncula, Federal University of Rio Grande do Sul, Brazil
2. Adenosine A2A receptor: a neuroglial effector in Alzheimer's Disease
David Blum, INSERM, University of Lille, France
3. Adenosine, stress & aging
Luisa V. Lopes, University of Lisbon, Portugal
4. Adenosine, mood & fear reactivity
Rodrigo Cunha, University of Coimbra, Portugal
5. 5. Oral Communication: To be announced
18:10 - 19:40 Poster Session
19:40 WELCOME PARTY
Wednesday, June 20, 2018
  Activity
8:30 - 9:15 Plenary Lecture 1: Purinergic Optopharmacology: Beyond the light.
Francisco Ciruela, University of Barcelona, Spain
Plenary lecture 2: Glial P2X7 receptors are indispensable mediators of the necrotic/apoptotic effect of ATP on neurons
Peter Illes, University of Leipzig, Germany
9:15 - 10:55
Symposium 4 - Purinergic Signaling in the cardiovascular system
Chairs: Ryszard T. Smolenski, Medical University of Gdansk, Poland
Maria Rosa Chitolina Schetinger, Federal University of Santa Maria, Brazil
1. P2Y-mediated signaling in lung vascular endothelial barrier strengthening
Alexander Verin, Augusta University, USA
2. The P2Y2 nucleotide receptor is an inhibitor of vascular calcification
Cheikh I. Seye, Indiana University School of Medicine, USA
3. HDAC inhibitor butyrate cooperates with A1 and A2B receptors to attenuate pulmonary artery vasa vasorum remodeling in hypoxia
Evgenia Gerasimovskaya, University of Colorado Denver
4. Protective effects of adenosine deaminase inhibition on tumor development and metastases
Ryszard T. Smolenski, Medical University of Gdansk, Poland
5. Oral Communication: Purinergic system: Platelets and illness
Daniela Leal, Federal University of Santa Maria, Brazil
Symposium 5 - Purinergic signaling in bone cell formation and disease
Chairs: Alison Gartland, University of Sheffield Medical School, United Kingdom
Niklas R. Jorgensen, University of Southern Denmark, Denmark
1. P2X7 receptor in prostate cancer bone metastasis initiating cells
Ning Wang, University of Sheffield, United Kingdom
2. P2X7 and multiple myeloma
Ankita Agrawal, Research Centre for Ageing and Osteoporosis, Department of Clinical Biochemistry, Rigshospitalet, Denmark
3. P2X7R in primary bone cancer
Luke Tattersall, The University of Sheffield, United Kingdom
4. Positive allosteric modulation of parathyroid hormone 1 receptor function by extracellular nucleotides
Peter Chidiac, The University of Western Ontario London, Canada
5. Oral Communication: NTPDase3 enzyme inhibition or gene silencing rescues the osteogenic potential of post-menopausal mesenchymal stem cells (MSCs) derived from bone marrow
Paulo Correia-de-Sá, University of PORTO, Porto, Portugal
Symposium 6 - Purinergic signaling in neuroregeneration and neuroprotection
Chairs: Esmerilda Delicado, Complutense University of Madrid, Spain
Beata Sperlagh, Hungarian Academy of Sciences, Hungary
1. Regulation of P2X7 receptor by Sp1 nuclear factor: role in neuroregeneration
Rosa Gomez-Villafuertes, Complutense University of Madrid, Spain
2. Impairment of P2Y2 receptor signaling by PGE2. Beneficial or detrimental in neuroinflammation?
Esmerilda Delicado, Complutense University of Madrid, Spain
3. Regulation of the celular proteostasis by the purinergic signaling. Relevance in neurological disorders
Miguel Diaz-Hernandez, Complutense University of Madrid, Spain
4. The role of P2Y12 receptors in animal models of Parkinson's disease
Beata Sperlagh, Hungarian Academy of Sciences, Hungary
5. Oral Communication: P2X7 receptors in ventral hippocampus are involved in stress response and antidepressant effect
Deidiane Elisa Ribeiro, São Paulo University
10:55 - 11:15 COFFEE BREAK
11:15- 12:55
Symposium 7 - Purinergic signaling in brain disease
Chairs: Francisco Ciruela, University of Barcelona, Spain
Carla Bonan, Pontifical Catholic University of Rio Grande do Sul, Brazil
1. A1 adenosine receptors in the striatum play a role in the impairment caused by sleep deprivation through downregulation of the PKA pathway
Debora Hipolide, Federal University of São Paulo, Brazil
2. Antidepressive actions of inosine
Manuella Kaster, Federal University of Santa Catarina, Brazil
3. Purinergic Signaling in models of neurological disorders in zebrafish
Carla Bonan, Pontifical Catholic University of Rio Grande do Sul, Brazil
4. Oral Communication: Purinergic Signaling in bipolar disease
Maria Carolina Bittencourt-Gonçalves, Federal University of São Paulo, Brazil
5. Oral Communication: New P2X7 receptor function highlighted in a mouse model of Alzheimer's disease
Cécile Delarasse, Institut Cerveau et Moelle Epinière, France
Symposium 8 - Purinergic signaling in chronic diseases
Chairs: Gary A. Weisman, University of Missouri, USA
Heitor S.P. de Souza, Federal University of Rio de Janeiro, Brazil
1. Targeting P2Y2 and P2X7 Receptors in Salivary Glands in the Autoimmune Disease Sjögren’s Syndrome
Gary A. Weisman, University of Missouri, USA
2. Fructose 1,6-bisphosphate, a glycolytic intermediate, regulates macrophage activation through adenosinergic-signaling pathway
José Carlos Farias Alves Filho, University of São Paulo, Brazil
3. Purinergic Signalling in Inflammatory Bowel Diseases
Heitor S.P. de Souza, Universidade Federal do Rio de Janeiro, Brazil
4. P2X7 receptor antagonist recovers ileum myenteric neurons after experimental ulcerative colitis
Patrícia Castelucci, University of São Paulo, Brazil
5. Oral Communication: Inhibition of AMP Deaminase is Cardioprotective in Acute Oxygen Deprivation
Magdalena Zabielska, Medical University of Gdansk, Poland
Symposium 9 - Purinergic signalling in cancer I
Chairs: Elena Adinolfi, University of Ferrara, Italy
Mariusz Ratajczak, University of Louisville, USA
1. CD73 as biomarker of advanced melanoma response to immunotherapy
Silvana Morello, University of Salerno, Italy
2. P2 receptors are involved in glioma progression
Fernanda Morrone, Pontifical Catholic University of Rio Grande do Sul, Brazil
3. P2X7 receptor splice variants A and B as oncogenes and predictors of response to chemotherapy: evidence from patients and murine experimental models
Elena Adinolfi, University of Ferrara, Italy
4. Novel evidence that extracellular nucleotides and purinergic signaling induce innate immunity-mediated mobilization of hematopoietic stem/progenitor cells
Mariusz Ratajczak, University of Louisville, USA
5. Oral Communication: Methotrexate reduces the glioblastoma growth by interfering with the adenosinergic system
Fabricio Figueiró, Federal Universty of Rio Grande do Sul, Brazil
12:55 - 14:30 LUNCH
14:30- 16:10
Symposium 10 - Purinergic signalling in cancer II
Chairs: John Stagg, University of Montreal, Canada
Simon Robson, Harvard Medical School, USA
1. Ubiquitination of tumor suppressor PML regulates CD73 to foster an immunosuppressive tumor microenvironment
Ruey-Hwa Chen, National Taiwan University, Taiwan
2. Purinergic signalling, zombie Tregs and cancer
Simon Robson, Harvard Medical School, USA
3. Disruption of adenosine A2a receptor signaling in mice impairs immune and metabolic homeostasis to promote liver carcinogenesis
John Stagg, University of Montreal, Canada
4. Oral Communication: Potential therapeutic application of anti-CD39 monoclonal antibodies
Paola Mello, Harvard Medical School, USA
5. Oral Communication: Role of the Adenosine A2B Receptors in behavior and maturation of normal and malignant stem cells
Lauren Sherman, New Jersey Medical School, Rutgers University, USA
Symposium 11 - Involvement of the purinergic system in pain
Chairs: Peter Illes, University of Leipzig, Germany
Fusao Kato, Jikei University, Japan
1. Microglial ATP receptors in neuropathic pain
Tomohiro Yamashita, Kyushu University, Japan
2. Acupuncture-induced analgesia
Yong Tang, Chengdu University, China
3. Chronic pain-associated plasticity in the emotional circuits - modulation by purines
Fusao Kato, Jikei University, Japan
4. Purinergic signalling in migraine pain
Rashid Giniatullin, University of Eastern Finland, Finland and Kazan Institute of Biophysics, Russia
5. Oral Communication: Bug off pain: probing P2X channels with venoms
Lucka Bibic, University of East Anglia, United Kingdom
Symposium 12 - Adenosine Neuromodulation: implications for epilepsy control
Chairs: Ana Maria Sebastião, University of Lisbon, Portugal
Detlev Boison, Legacy Research Institute, USA
1. Adenosine kinase - target for the prevention of epilepsy
Detlev Boison, Legacy Research Institute, USA
2. Synaptic targets for adenosine to control excitability and plasticity.
Ana M Sebastião, University of Lisbon, Portugal
3. Excitability: Models and Mechanisms
Susan Masino, Trinity College Hartford, USA
4. Enhancing adenosine release for seizure control
Bruno Frenguelli, University of Warwick, United Kingdom
5. Oral Communication: Adenosine as potential modulator of olfactory sensory information processing
Daniela Hirnet, University of Hamburg, Germany
16:10 - 16h30 COFFEE BREAK
16:30 - 18:10
Symposium 13 - Medicinal Chemistry of Purinergic Signalling
Chairs: Christa Müller, University of Bonn, Germany
Antonia Tavares do Amaral, University of São Paulo, Brazil
1. A2B adenosine receptors: novel tools and new roles
Christa Müller, University of Bonn, Germany
2. Virtual screening search of bioactive compounds for CD73: Importance of experimental validation and conformational flexibility
Antonia Tavares do Amaral, University of São Paulo, Brazil
3. A new fast, selective and highly sensitive fluorescence-based assay for monitoring nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39)
Sangyong Lee, University of Bonn, Germany
4. Oral Communication: A rapid method to probe P2X7 receptor heterologous expression in a plate reader and the discovery of a new entity ATP responsive in HEK293T Cells
Monica Santos de Freitas, Federal University of Rio de Janeiro, Brazil
5. Oral Communication: Mapping the binding site for the P2X7 receptor antagonist AZ11645373
Anfal Bin Dayel, University of Leicester, United Kingdom
Symposium 14 - Adenosine signaling in the retina
Chairs: Roberto Paes de Carvalho, Fluminense Federal University, Brazil
António Francisco Ambrósio, University of Coimbra, Portugal
1. Adenosine signaling and the daily control of photoreceptor electrical coupling
John O´Brien, University of Texas Health Science Center, USA
2. Neuromodulation by adenosine in the developing retina
Roberto Paes-de-Carvalho, Federal Fluminense University, Brazil
3. Caffeine effects in the developing retina
Karin da Costa Calaza, Federal Fluminense University, Brazil
4. Targeting adenosine receptors for the treatment of retinal degenerative diseases
Antonio F. Ambrósio, University of Coimbra, Portugal
5. Oral Communication: New mechanisms of regulation of adenosine transporters in the retina
Alexandre dos Santos Rodrigues, Federal Fluminense University, Brazil
Symposium 15 - Purinergic signaling via calcium signaling
Chairs: Robson Coutinho-Silva, Federal University of Rio de Janeiro, Brazil
Andrew Thomas, The State University of New Jersey, USA
1. Differential actions of purinergic receptors on calcium signaling in the liver
Andrew Thomas, The State University of New Jersey, USA
2. Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity
Alejandro Caicedo, University of Miami, USA,
3. P2X4-dependent calcium signals and cytokine secretion in human macrophage
Samuel J. Fountain, University of East Anglia, United Kingdom
4. Oral Communication: Adenosine A3 receptor stimulation inhibits pro-nociceptive voltage-dependent Ca2+ currents in rat dorsal root ganglion neurons
Elisabetta Coppi, University of Florence, Italy
5. Oral Communication: Oral Communication: P2X7 receptor is a key modulator of energy cell metabolism
Alba Clara Sarti, University of Ferrara, Italy
18:10 - 19:40 Poster Session
19:40 Assembly Brazilian Purine Club/European Purine Club
Thursday, June 21, 2018
  Activity
8:30 - 9:15 Plenary Lecture 3: Regulation of cellular energy balance by the P2X7 receptor
Francesco di Virgilio, University of Ferrara, Italy
Plenary Lecture 4: NTPDase8 prevents intestinal inflammation by blocking P2Y receptor activation
Jean Sèvigny, Université Laval, Canada
9:15 - 10:55
Symposium 16 - Purinergic transmission in glial cells
Chairs: Schuichi Koizumi, University of Yamanashi, Japan
Christian Lohr, University of Hamburg, Germany
1. Purinergic neuron-glia communication in the olfactory bulb.
Christian Lohr, University of Hamburg, Germany
2. Ischemic tolerance and glial purinergic signaling
Schuichi Koizumi, University of Yamanashi, Japan
3. Diversity of purinergic Ca2+ signals in oligodendrocytes and astrocytes
Frank Kirchhoff, University of Saarland, Germany
4. P2X7 receptor signaling in Muller glia: role of glutathione and GABA
Ricardo Reis, Federal University of Rio de Janeiro, Brazil
5. Oral Communication: Inhibition of E-NTPDases regulates proliferation by P2Y1 receptor and modulates cell death in rat retinal progenitors
Marinna Garcia Repossi, Federal Fluminense University, Brazil
Symposium 17 - Purines in the Eye
Chairs: Claire H. Mitchell, University of Pennsylvania, USA
Ana Lucia Marques Ventura, Fluminense Federal University, Brazil
1. Release of lysosomal ATP from astrocytes and epithelial cells triggered by TLR3 activation
Claire H. Mitchell, University of Pennsylvania, USA
2. Regulation of retinal progenitors proliferation by P2 receptors
Lucianne Fragel Madeira, Fluminense Federal University, Brazil
3. Role of ATP and P2X7 receptor in the regulation of the regenerative response in the injured retina of adult zebrafish
Maria Paula Faillace, University of Buenos Aires, Argentina
4. Inosine and nucleotide signaling in the developing avian retina
Ana Lucia Marques Ventura, Fluminense Federal University, Brazil
5. Oral communication: Cannabinoids induce cell death and modulates P2X7 receptor-mediated calcium responses in developing retinal cell cultures
Guilherme Rapozeiro França, Federal University of the State of Rio de Janeiro, Brazil
Symposium 18 - Purinergic Signaling in metabolic and degenerative diseases
Chairs: Ivana Novak, University of Copenhagen, Denmark
Maria Rosa Chitolina Schetinger, Federal University of Santa Maria, Brazil
1. ADP accelerates chronic wound healing in diabetic mice
Claudia Farias Benjamim, Federal University of Rio de Janeiro, Brazil
2. Role of purinergic signalling in insulin secretion and insulin sensitivity
Ivana Novak, University of Copenhagen, Denmark
3. Evaluation of nucleotide hydrolysis of obese patients given clinical treatment and bariatric surgery
Maria Rosa Chitolina Schetinger, Federal University of Santa Maria, Brazil
4. Oral Communication: P2X7 receptor and Klotho expressions in diabetic nephropathy progression
Elisa Mieko Suemitsu Higa, Federal University of São Paulo, Brazil
5. Oral Communication: The effect of adenosine A2A receptor stimulation on mitochondrial metabolism in the pathogenesis and treatment of osteoarthritis
Cristina M. Castro, New York University School of Medicine, USA
10:55 - 11:15 COFFEE BREAK
11:15- 12:55
Symposium 19 - Endocrine Purinergic Signaling
Chair: Zulma Ferreira, Universidade de São Paulo, Brazil
Charlotte von Gall, Heinrich-Heine University Düsseldorf, Germany
1. Purinergic signaling in the immune-pineal axis
Zulma Ferreira, University of São Paulo, Brazil
2. Distribution of purinergic receptors in the mouse suprachiasmatic nucleus and hippocampus
Charlotte von Gall, Heinrich-Heine University Düsseldorf, Germany
3. Circadian micturition rhythm coordinated by bladder clock and connexin43
Hiromitsu Negoro, Tsukuba University, Japan 4. To be announced
4. Oral Communication: The ergogenic effects of caffeine depend on A2A receptors
Aderbal Silva Aguiar Junior, Federal University of Santa Catarina, Brazil.
5. Oral Communication: Adenosine A1 receptors inhibit ejaculation at multiple sites
Luiz Ricardo de Almeida Kiguti, Campinas State University, Brazil
Symposium 20 - Purinergic signaling in stem cell proliferation and differentiation
Chairs: Marcia Wink, Federal University of Health Sciences of Porto Alegre, Brazil
Claudiana Lameu, University of São Paulo, Brazil
1. Purinergic signaling in mesenchymal stem cell differentiation.
Edda Tobiasch, Bonn-Rhein-Sieg University, Germany
2. Extracellular Nucleotide Hydrolysis in Dermal and Limbal Mesenchymal Stem Cells: A Source of Adenosine Production
Marcia Wink, Federal University of Health Sciences of Porto Alegre, Brazil
3. Purinergic Signaling in the maintenance of cancer stem cells and neuroblastoma metastasis
Claudiana Lameu, University of São Paulo, Brazil
4. Why do mesenchymal stem cells sense the nucleotide signal in a different way?
Katarzyna Roszek, Nicolaus Copernicus University, Poland
5. Oral Communication: ATP and calcium oscillations in Huntington’s disease: targeting neural stem cells
Talita Glaser, University of São Paulo, Brazil
Symposium 21 - Guanine-based Purines in Brain Physiology and Pathology
Chairs: Diogo Souza, Federal University of Rio Grande do Sul, Brazil
Francesco Caciagli, University of Chieti-Pescara, Italy
1. Neuroptotective effects of guanosine in experimental protocols of brain diseases
Diogo Souza, Federal University of Rio Grande do Sul, Brazil
2. Guanosine promotes proliferation in neural stem cells and neurogenesis in hippocampus and subventricular zone from adult mice
Carla I. Tasca, Federal University of Santa Catarina, Brazil
3. The integrated activity of the Guanosine-Guanine and their respective converting enzymes system opens new pharmacological perspectives.
Francesco Caciagli, University of Chieti-Pescara, Italy
4. Oral Communication: Guanosine treatment improves the long-term behavioral changes induced by olfactory bulbectomy an animal model of depression
Roberto Almeida, Federal University of Rio Grande do Sul, Brazil
5. Oral Communication: Guanosine Antiparkinsonian Efficacy in Rodent Models of movement Disorders
Caio Marcos Massari Leite, Federal University of Santa Catarina, Brazil
12:55 - 14:30 LUNCH
14:35 - 15:15 Plenary Lecture 5: P2X7 receptor in inflammatory diseases: Angel or demon?
Robson Coutinho Silva - Federal University of Rio de Janeiro, Brazil
Plenary Lecture 6: In the Eye of the Storm: Adenosine, Cartilage and Arthritis
Bruce N. Cronstein, New York University School of Medicine, USA
15:15- 16:55
Symposium 22 - Coffee: Caffeine and Beyond
Chairs: Sergi Ferré - National Institute on Drug Abuse-IRP, NIH, DHHS, USA
Rui D. Prediger, Federal University of Santa Catarina, Brazil
1. Mechanisms of the psychostimulant effects of caffeine
Sergi Ferré, National Institute on Drug Abuse-IRP, NIH, DHHS, USA
2. Caffeine targets adenosine A1-dopamine D1 receptor heteromers that modulate the excitability of the spinal motoneuron
Manuel Diaz-Rios, University of Puerto Rico, Puerto Rico
3. Caffeine and selective adenosine antagonists reverse the effort-related motivational effects of impaired dopamine transmission: potential relevance for psychiatric and neurological disorders
John Salamone, University of Connecticut, USA
4. Caffeine improves cognitive and emotional impairments in Attention Deficit Hyperactivity Disorder (ADHD)
Rui Prediger, Federal Universty of de Santa Catarina, Brazil
5. Oral communication: The role of coffee constituents other than caffeine on CSK/Src pathway in the Central Nervous System
Marcelo Cossenza, Fluminense Federal University, Brazil
Symposium 23 - Purinergic signaling in plants
Chairs: Gary Stacey, University of Missouri, USA
Stanley Roux, University of Texas, USA
1. Elucidation of multiple plant purinergic receptors and aspects of their associated signaling pathways
Gary Stacey, University of Missouri, USA
2. Ectopic expression of an apyrase from Pisum sativum enhances root system architecture and drought tolerance in plants
Stanley Roux, University of Texas, USA
3. Populus euphratica apyrase2 enhances cold tolerance in Arabidopsis plants
Shaoliang Chen, Beijing Forestry University, China
4. Extracellular pyridine nucleotides in plant immunity
Zhonglin Mou, University of Florida, USA
5. Oral Communication: Extracellular ATP DAMPens plant disease by boosting immunity
Kiwamu Tanaka, Washington State University, USA
Symposium 24 - Purines in glial regulation of brain synapses and networks
Chairs: Eric Boué-Grabot, University of Bordeaux, France
Yuriy Pankratov, University of Warwick, United Kingdom
1. New P2X4mCherryIN knockin transgenic mice expressing non-internalized P2X4 receptors revealed alteration in hippocampal plasticity and memory
Eric Boué-Grabot, University of Bordeaux, France
2. Glial mechanisms of central respiratory chemosensing
Vishaal Rajani, University College London, London, United Kingdom
3. Adenosine signalling regulates inhibitory synaptogenesis in the hippocampus
Sabine Lévi, Institut du Fer à Moulin, France
4. Role for astroglia-derived ATP in gliotransmission and control of synaptic plasticity in neocortex
Yuriy Pankratov, University of Warwick, United Kingdom
5. Oral communication: To be announced
16:55 - 17:15 COFFEE BREAK
17:15 - 18:55
Symposium 25 - Purinergic signaling and immunomodulation
Chairs: Gabriele Baier, Medical University of Innsbruck, Austria
Vinicius de Frias Carvalho, Oswaldo Cruz Foundation- FIOCRUZ, Brazil
1. LASSBio – 897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A2A Receptor
Vinicius F. Carvalho, Oswaldo Cruz Foundation (FIOCRUZ), Brazil
2. Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation
Fritz Koch-Nolte, University Medical Center Hamburg, Germany
3. ADORA2A-mediated protection of ischemia-reperfusion injury. Role of protein kinase N1: A new player in the pathophysiology of experimental stroke
Gabriele Baier, Medical University of Innsbruck, Austria
4. Oral Communication: P2X7 receptor and metabolism of CD4+ T cell during experimental malaria
Érika Machado de Salles, University of São Paulo, Brazil
5. Oral Communication: The A2aR signaling pathway as candidate Immune checkpoint in the T cell compartment
Gottfried Baier, Medical University of Innsbruck, Austria
Symposium 26 - Structure-function aspects of Purine receptors
Chairs: Kenneth A. Jacobson, National Institute of Health, USA,
Richard J Evans, University of Leicester, United Kingdom
1. Structure-guided discovery of adenosine receptor ligands
Jens Carlsson, Uppsala University, Sweden
2. Structure-based drug discovery of P2Y receptor ligands
Kenneth A. Jacobson, National Institutes of Health, USA
3. Structure and functional reconstitution of the P2X7 receptor
Toshimitsu Kawate, Cornell University, USA
4. Integrating mutagenesis, biochemical and modelling approaches to understand P2X receptor properties
Richard J. Evans, University of Leicester, United Kingdom and Ralf Schmid, University of Leicester, United Kingdom
5. Oral Communication: Harnessing herbs to potentiate P2X7: elucidating the binding site of ginsenoside CK on P2X7
Stefan Bidula, University of East Anglia, United Kingdom
Symposium 27 - Oral Communications
Chairs: Ana Maria Battastini, Federal University of Rio Grande do Sul, Brazil
Samuel Fountain, University of East Anglia, United Kingdom
1. A2AR stimulation suppresses CD8+ T cells activity by inhibition of Notch1 signalling
Claudia Sorrentino, University of Salerno, Italy
2. An altered nucleotide metabolism as a novel mechanism leading to Huntington disease related cardiomyopathy
Marta Toczek, Gdansk University, Poland
3. The first transmembrane domain residues regulate rat P2X7 receptor trafficking and gating
Marian Rupert, Academy of Sciences of the Czech Republic
4. Combined in silico plus electrophysiological studies identify molecular determinants of ivermectin and zinc P2X4R allosterism
Juan Pablo Garcia-Huidobro Toro, University of Santiago de Chile, Chile
5. The extracellular NAD+ and NMN metabolism on the surface of human aortic valves
Patrycja Jabłońska, Medical University of Gdansk, Poland
6. Signaling at adenosine A2A receptors (A2aR); crosstalk with Wnt/β-catenin signaling pathway in osteoblasts
Soheila Borhani, New York University School of Medicine, USA
20:30 SOCIAL DINNER
Friday, June 22, 2018
  Activity
8:30 - 9:15 Plenary Lecture 7: Dynamics of purinergic signalling in the hearing organ
Gary Housley, University of New South Wales, Australia
Plenary Lecture 8: Therapeutic potential of CD39
Simon Robson, Harvard Medical School, USA
DIAMOND SPONSOR LECTURE: TissueFAXS Cytometry – A Tool for Precision Medicine: Automated Analysis of Single Cells and the Cellular MicroenvironmentPlenary Lecture 8: Therapeutic potential of CD39
Rupert Ecker, TissueGnostics, Austria: Tissue Cytometry
9:15 - 10:55
Symposium 28 - Oral communications
Chairs: Henning Ulrich, University of São Paulo, Brazil
Cláudia Mara Lara Melo Coutinho, Fluminense Federal University, Brazil
1. Dichlorvos exposure at early stages of development alters ecto-5’-nucleotidase and ecto-ADA activities in adult zebrafish (Danio rerio) brain
Stefani Altenhofen, Pontifical Catholic University of Rio Grande do Sul, Brazil
2. The effect of changes in the CD73 activity on the aortic valve and endothelium function in mice
Paulina Zukowska, Medical University of Gdansk, Poland
3. Early human sepsis modulates purinergic receptors expression, serum ATP levels and ATPase activity
Rafael Olivé Leite, Federal University of Pelotas, Brazil
4. The significance of nucleoside diphosphate kinase (NDPK)-dependent transphosphorylation for ADP/ATP carrier (AAC)-mediated mitochondrial proton leak of yeast Saccharomyces cerevisiae
Andrzej Woyda-Ploszczyca, Faculty of Biology, Adam Mickiwicz, Adam Mickiewicz, Polandd
5. P2X7B isoform role in chemoresistance and epithelial-to-mesenchymal transition of human neuroblastoma cells
Vanessa Fernandes Arnaud Sampaio University of São Paulo, Brazil
6. Cardiac mitochondria function and extracellular vascular nucleotide metabolism in genetic model of hyperlipidemia
Alicja Bulinska University of Gdansk, Poland
Symposium 29 - Purinergic signaling and inflammation
Chairs: Ronald Sluyter, Illawarra Health and Medical Research Institute, Australia
Tiana Tasca, Federal University of Rio Grande do Sul, Brazil
1. Pro-inflammatory role of the ATP/P2X7 signalling axis in graft-versus-host disease in humanised mice
Ronald Sluyter, Illawarra Health and Medical Research Institute, Australia.
2. Modulating P2X7 – which way do we go?
Leanne Stokes, Universty of East Anglia, United Kingdom
3. Oral Communication: CD39 Limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury
Luiz Eduardo Baggio Savio, Federal University of Rio de Janeiro, Brazil
4. Oral Communication: Stimulation of adenosine A2A receptors regenerates cartilage in osteoarthritis model
Ane Larranaga-Vera, New York University Langone Health, USA
5. Oral Communication: Nucleotide and adenosine converting ecto-enzyme pattern in endothelial inflammation
Barbara Kutryb-zajac, Medical University of Gdansk, Gdansk, Poland
Symposium 30 - Purinergic signaling in lung disease
Chairs: - Patricia Machado R. e Silva Martins, Oswaldo Cruz Foundation (FIOCRUZ), Brazil
György Haskó, Rutgers New Jersey Medical School, USA
1. Extracellular ATP in sepsis
Dr. György Haskó, Rutgers New Jersey Medical School, USA
2. Role of adenosine in lung fibrosis caused by silica particles
Patricia Machado Rodrigues e Silva Martins, Oswaldo Cruz Foundation (FIOCRUZ), Brazil
3. Purinergic-dependent contraction of small intrapulmonary veins: role in a pulmonary arterial hypertension rat model
Mauricio Henriquez, University of Chile, Chile
4. Purinergic signaling and the genesis of lung immunopathology during respiratory virus infections
Victor H Leyva-Grado DVM, Icahn School of Medicine at Mount Sinai, USA
5. Oral Communication: To be announced
10:55 - 11:15 COFFEE BREAK
11:15- 12:55
Symposium 31 - Purinergic signaling in the ear
Chairs: Gary Housley, University of New South Wales, Australia
Peter Thorne, University of Auckland, New Zealand
1. Transcriptome profile of purinergic hearing adaptation
Gary Housley, University of New South Wales, Australia
2. Cochlear rescue from noise-induced hearing loss by inhibition of the molecular complex which regulates adenosine A1 receptor signalling
Srdjan Vlajkovic, University of Auckland, New Zealand
3. A model for P1 and P2 receptor interaction in regulating cell injury and repair in the cochlea
Peter Thorne, University of Auckland, New Zealand
4. ATP-activated Ca2+ signaling in supporting cells of the organ of Corti in the hearing mouse hemicochlea
Tibor Zelles, Hungarian Academy of Sciences, Hungary
5. Oral Communication: Purinergic hearing adaptation to sustained sound
Jennie Cederholm, University of New South Wales, Australia
Symposium 32 -New insights on structure and functions of ectonucleotidases
Chairs: Jean Sèvigny, Université Laval, Canada
Elizandra Braganhol, Federal University of Health Sciences of Porto Alegre, Brazil
1. Disturbances in purinergic signaling as part of the pathophysiology of hypophosphatasia
Jose Luis Millan - Sanford Burnham Prebys Medical Discovery Institute, USA
2. CD73 as target for glioblastoma therapy
Elizandra Braganhol, Federal University of Health Sciences of Porto Alegre, Brazil
3. Identification of new scaffolds as inhibitors of NTPDases and NPPs: Structural, Mechanistic and In-silico Studies
Jamshed Iqbal Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Pakistan
4. NTPDase8 regulates integrity and immune function of intestinal epithelial cells
Salem Mabrouka, Université Laval, Canada
5. Oral Communication: Deletion of CD73 leads to the shifts of NAD metabolism
Ewa Maria Slominska, University of Gdansk, Poland
Symposium 33 - Central nervous system regulation by purinergic receptors
Chairs: Gregory D. Funk, University of Alberta, Canada
Thiago Moreira, University of São Paulo, Brazil
1. Purinergic regulation of breathing
Gregory D. Funk, University of Alberta, Canada,
2. Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe
Thiago Moreira, University of São Paulo, Brazil
3. Purinergic Signaling at Hypothalamus Level: Mechanistic Insights Involved in the Control of Salt-Induced Sympathoexcitation
Vagner Antunes, University of São Paulo, Brazil
4. Astrocyte P2X1 receptors in cortical neurovascular coupling
Anusha Mishra, Oregon Health & Science University, USA
5. Oral Communication: Re-evaluation of P2X7 expression in the central and peripheral nervous system using novel mouse models
Annette Nicke, LMU Munich, Germany
12:55 - 14:30 LUNCH
14:30 - 16:30
Symposium 34 - Electrophysiology and functions of purinergic receptors
Chairs: Günther Schmalzing, University of Aachen, Germany
Wolfgang Nörenberg University of Leipzig, Germany
1. Interaction of P2X7 receptors with other ion channels
Fritz Markwardt, University of Halle, Germany
2. Cation currents in tumor cells - the Janus face of P2X7 and TRPM7
Wolfgang Nörenberg, University of Leipzig, Germany
3. Modulation of P2X receptor functions by cytoplasmic tails
Günther Schmalzing, University of Aachen, Germany
4. Identification of neurosteroids that are able to interact with allosteric binding sites on purinergic P2X receptors
Hana Zemkova, Academy of Sciences of the Czech Republic, Czech Republic
5. Oral Communication: Hits identified by high-throughput screening at the non-desensitizing S15V-rP2X3 receptor
Astrid Obrecht, University of Aachen, Germany
Symposium 35 - Purinergic signalling in cancer III
Chairs: Renata Ciccarelli, University of Chieti-Pescara, Italy
Ivana Novak, University of Copenhagen, Denmark
1. Effect of P2X7 modulation on the survival and aggressiveness of cancer stem cells from human glioblastoma multiforme
Renata Ciccarelli, University of Chieti-Pescara, Italy
2. Purinergic signaling in pancreatic cancer
Ivana Novak, University of Copenhagen, Denmark
3. Extracellular nucleotides drive the epithelial or mesenchymal phenotype induction in ovarian carcinoma cells
Francisco Gabriel Vázquez-Cuevas, National Autonomous University of Mexico, Mexico
4. Regulation of intratumoral purine homeostasis and signaling via concerted action of alkaline phosphatases, CD39 and CD73
Gennady Yegutkin, Turku University, Finland
5. Oral Communication: P2X7 suppression as a new innovative treatment option for tumors with lost or mutated p53
Carlotta Giorgi, University of Ferrara, Italy
Symposium 36 - Adenosine receptor signaling in neurological and psychiatric disorders
Chairs: Jiang-Fan Chen, Boston University School of Medicine, USA/Wenzhou Medical University, China
Zhi-Li Huang, Fudan University, China
1. Adenosine A2A receptors and Parkinson's disease: benefits and challenges.
Jiang-Fan Chen, Boston University School of Medicine, USA/ Wenzhou Medical University, China
2. The role of adenosine A2A receptor on the tauopathy and cognitive disorder after traumatic brain injury
Yuanguo Zhou, The Third Military Medical University, China
3. To be announced
4. Adenosine A2A and Dopamine D1 Receptors in the Basal Ganglia Regulate Sleep-wake Cycle.
Zhi-Li Huang, Fudan University, China
5. Oral Communication: Adenosine A2A receptor signaling in Huntington disease.
Yijuang Chern, Academy of Science, Taiwan
16:10 - 16:30 COFFEE BREAK
16:30 - 18:10
Symposium 37: Acupuncture
Chairs: Yong Tang, Chengdu University of Traditional Chinese Medicine
Jiang-Fan Chen, Boston University, USA
1. Regulation of acupuncture and moxibustion on purine receptors in IBS visceral pain
Huirong Liu, Shanghai Research Institute of Acupuncture and Meridian, China
2. CD39 and CD73: targets for immune regulation by moxibustion
Qiaofeng Wu, Chengdu University of Traditional Chinese Medicine, China
3. P2X3 and acupuncture analgesia
Yongliang Jiang, Zhejiang University of Traditional Chinese Medicine, China
4. P2X7 and acupuncture mechanism
Haiyan Yin, Chengdu University of Traditional Chinese Medicine, China
5. Oral Communication: Tera Hertz-induced analgesia at acupoint and Purinergic Signaling
Liang Kang, Chengdu University of Traditional Chinese Medicine, China
Symposium 38: Imaging and electrophysiology for the study of purinergic signaling
Chairs: Zoltan Gerevich, Charité - University Medicine Berlin, Germany
Ivan Milenkovic, University of Leipzig, Germany
1. Neuronal network effects of P2 receptors in schizophrenia
Zoltan Gerevich, Charité - University Medicine Berlin, Germany
2. Role of astroglial purinergic signaling in Alzheimer’s disease
Nicole Reichenbach, German Center for Neurodegenerative Diseases, Germany
3. Signaling function of ATP in the central auditory system
Ivan Milenkovic, University of Leipzig, Germany
4. Dual control of microglial motility by ATP and membrane voltage
Christian Madry, Charité - University Medicine Berlin, Germany
5. Oral communication: Cytosolic Ca2+ transients evoked by purinergic receptors in hepatocytes: the role of P2Y receptors
Juliana Corrêa-Velloso - University of São Paulo, Brazil
Workshop: Meet the Editors – Publishing in Science
This workshop is designed to provide Junior Scientists with an opportunity learn more about the publishing process and to meet with several Editors. During the first 60 minutes the Editors will cover a range of topics from manuscript preparation and submission, editorial handling and triage, peer review, decision making and resubmission, publishing ethics (plagiarism/fabrication/falsification), open access publishing, and pre-print servers. Those topics will be covered in an interactive way with appropriate time for Q&As. The final 30 minutes of this 90 minute workshop will follow a ‘speed dating’ model, where the workshop audience is given the opportunity for brief one on one interactions with each of the Editors
Meet the Editors:
Detlev Boison, Associate Editor, Frontiers in Molecular Neuroscience
Sergi Ferré, Editor-in-Chief, Journal of Caffeine and Adenosine Research
Bruno Frenguelli, Editor-in-Chief, Neuropharmacology
Ana Maria Sebastião, Handling Editor, Journal of Neurochemistry
Christa Müller, Associate Editor, MedChemComm
18:10 - 18:55 Plenary Lecture 9: Purinergic Signalling in neuronal differentiation and neurodegeneration: From in vitro studies towards therapeutic applications
Henning Ulrich, University of São Paulo, Brazil
18:55

Closing Remarks and Announcement of Purines 2020