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On behalf of the Brazilian Purine Club and the Organizing Committee of Purines 2018 International - Basic and translational science on purinergic signaling and its components for a healthy and better world, it is our pleasure to announce the upcoming congress, which will take place at the Mabu Thermas & Resort, in Foz do Iguaçu, Brazil, from June 19 to 22, 2018.

The historical term "Purinergic Signaling" includes signaling mechanisms by extracellular purines and pyrimidines and their derivatives. Considering that purinergic signaling contributes to almost all cell signaling events, the current challenge is to understand the integrated functions of purinergic and pyrimidinergic signaling and their implications in the context of imbalance of the homeostasis, as in the regards to diseases.

Recent research has revealed the importance of purinergic signaling in developmental processes, senescence, aging, neurodegeneration, immune response, inflammation, the sensation of pain, cancer and other chronic diseases, providing numerous targets for therapeutic interventions.

The purpose of Purines 2018 International is to gather the most renowned researchers from around the world, from the various areas of purinergic signaling, to create knowledge networks, to foster collaboration, to elaborate on new paradigms, and to integrate various systems.

The conferences, and symposia organized by experts in the field, will focus on state of the art knowledge with perspectives on pharmacological applications. Additionally, the work presented by students and the new generation of scientists will bring new ideas and help foster scientific collaboration and build new networks between the attendees.

We look forward to seeing you in Foz do Iguaçu!